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The risk of venous thromboembolism in oral contraceptive pill users becomes dramatically increased in patients with inherited thrombophilias. The often undiscovered prothrombotic genetic conditions pose a potentially deadly threat to its generally young demographic. When thrombosis is discovered in oral contraceptive pill users with a strong family history of related events, it becomes essential to screen for prothrombotic genetic conditions and further mitigate any associated modifiable risk factors. Here we present a case of pulmonary embolism requiring cardiopulmonary resuscitation in 30-year-old female found to have a Prothrombin G20210A on oral contraceptive pills. The emergent management of the critical case, as well as the subsequent evaluation for prothrombotic conditions and the role of potential screening is discussed.
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Darwish N, Bakillah H, Arun G, Srinivas S, Manaa M, Berliner K, Reddy D. Risk of Venous Thromboembolism: The Prothrombin-G20210A Mutation and Combined Oral Contraceptives. Advances in Clinical Medical Research and Healthcare Delivery. 2022; 2(2). doi: 10.53785/2769-2779.1097.