Kounis syndrome – Anaphylaxis-induced acute coronary syndrome

Authors

Austin T. Thacker DO, Rochester Regional Health SystemFollow
Brachman Herzig OMS, Lake Erie College of Osteopathic Medicine -Erie Campus,Follow
Brendan Robinson DO, United Memorial Medical Center -Rochester Regional Health.Follow
Ahad Anjum DO, Rochester Regional Health SystemFollow

Author Credentials

Austin Thacker, DO PGY-2

Brachman Herzig, OMS-III

Brendan Robinson, DO

Ahad Anjum, DO

Abstract

Kounis syndrome is an underdiagnosed condition in which anaphylaxis triggers vasospastic acute coronary syndrome, either with or without underlying coronary artery disease. The prevalence of this syndrome among hospitalized patients for allergic/hypersensitivity/anaphylactic reactions in the United States is 1.1%, with a 7% rate of all-cause inpatient mortality. This article presents an anaphylaxis-induced acute coronary syndrome case in a patient with underlying coronary artery disease. The pathophysiological mechanism of anaphylactic-induced acute coronary syndrome involves the inflammatory mediators of type I hypersensitivity reactions.

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Recommended Citation

Thacker AT, Herzig B, Robinson B, Anjum A. Kounis syndrome – Anaphylaxis-induced acute coronary syndrome. Advances in Clinical Medical Research and Healthcare Delivery. 2023; 3(4). doi: 10.53785/2769-2779.1178.