Recurrence of Basal Plate Myofibers, with Further Consideration of Pathogenesis

Department

Pathology

Document Type

Article

Publication Title

Fetal And Pediatric Pathology

Abstract

OBJECTIVES: Basal plate myofibers (BPMF) may indicate morbid adherence. We assessed recurrence and clinical progression of BPMF. METHODS: In 5 years, 135 BPMF placentas were reported. Controls were the first 50 placentas in 2009, none of which had reported BPMF. RESULTS: 32% of BPMF patients had other placentas, with a recurrence rate of 100%. Actin stains were needed for diagnosis in 117/179 cases (65%). These cases had clinical features suggestive of morbid adherence in 69/117 (59%). 23/47 (49%) of BPMF recurrences progressed in severity, 5 to hysterectomy (11%). Thinning of the basal plate, perforating vessels, gaps in the basal plate, and villi under the basal plate were observed in BPMF placentas. CONCLUSIONS: These findings appear to validate screening for BPMF. The 100% recurrence rate suggests evaluation for a heritable factor, i.e., protease inhibitor deficiency, which may explain pre-delivery basal plate damage.

First Page

30

Last Page

43

DOI

10.1080/15513815.2018.1546356

Volume

38

Issue

1

Publication Date

2-1-2019

Medical Subject Headings

Female; Humans; Placenta (pathology); Pregnancy; Recurrence

PubMed ID

30588864

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