Title

Diagnostic Challenges in Anaphylaxis

Department

Allergy and Immunology

Document Type

Article

Publication Title

The journal of allergy and clinical immunology. In practice

Abstract

Anaphylaxis is a severe and potentially life-threatening allergic reaction. Since its discovery over 100 years ago, research has led to great strides in describing pathophysiologic mechanisms of anaphylaxis; however, there is still imprecision regarding its definition and a lack of reliable, confirmatory testing. In this paper, we review definitions of anaphylaxis, highlighting studies examining the utility of the current clinical consensus definition. In addition, we evaluate current difficulties and limitations for both providers in acute care settings managing episodes and allergists evaluating patients after an episode has resolved. Finally, we provide an algorithm for outpatient evaluation of patients with a history of possible anaphylaxis.

First Page

1177

Last Page

1184

DOI

10.1016/j.jaip.2019.11.003

Publication Date

4-12-2020

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