Incidence of Respiratory Syncytial Virus Infection among Hospitalized Adults, 2017-2020


Infectious Diseases

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Clinical Infectious Diseases


Background: Respiratorysyncytialvirus (RSV)infection causes acuterespiratory illness and triggers exacerbations of cardiopulmonary disease. Estimates of RSVincidence inhospitalizedadults range widely, and few data exist onincidence inadults with comorbidities that increase the risk of severe disease. We conducted a prospective, population-based, surveillance study to estimateincidence of RSVhospitalization amongadults overall and those with specific comorbidities.

Methods: Hospitalizedadults ≥18 years residing in the surveillance area with ≥2 ARI symptoms or exacerbation of underlying cardiopulmonary disease were screened for eligibility during the2017-2018, 2018-2019, and 2019-2020 RSV seasons in threehospital systems in Rochester, NY and New York City.Respiratory specimens were tested for RSV using PCR assays. RSVincidence per 100,000 was adjusted by market share.

Results: During three winter seasons a combination of active and passive surveillance identified 1,099adultshospitalized with RSV at three medical centers. Annualincidence during three seasons ranged from 44.2-58.9/100,000. Age-group specificincidence ranged from 7.7-11.9/100,000, 33.5-57.5/100,000, and 136.9-255.6/100,000 in patients 18-49, 50-64, and >65-years of age, respectively.Incidence rates in patients with chronic obstructive pulmonary disease, coronary artery disease, and congestive heart failure were 3-13, 4-7, 4-33 times theincidence in patients without these conditions.

Conclusions: We found a high burden of RSVhospitalization in this large prospective study. Notable was the highincidence of RSVhospitalization among older patients and those with cardiac conditions. These data confirm the need for effective vaccines to prevent RSVinfection in older and vulnerableadults.

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See full author list https://pubmed.ncbi.nlm.nih.gov/34244735/