Spot Urine Protein/Creatinine Ratio as an Alternative to 24-Hour Urine Collection for Measuring Proteinuria in Patients With Multiple Myeloma: A Prospective Study

Department

Oncology and Hematology

Additional Department

Internal Medicine

Document Type

Article

Publication Title

Clinical Lymphoma, Myeloma & Leukemia

Abstract

Measurement of 24- hour urine protein electrophoresis (PEP) and immunofixation (IFE) are part of standard diagnostic evaluation and monitoring of patients with suspected and diagnosed monoclonal plasma cell disorder for baseline evaluation of renal dysfunction or nephrotic syndrome. Measurement of 24-hour urine protein can however be time consuming and cumbersome and many centers have moved towards random urine protein measurements. The evidence for correlation between spot urine protein creatinine ratio (SUPC) and 24-hour urine protein measurements its scarce. Therefore, we have carried out a prospective study with a sample size of 40 multiple myeloma (MM) patients to demonstrate this correlation. Our results suggest a good correlation between SUPC and 24-hour urine protein measurements, suggesting SUPC testing is a reliable and easier alternative to 24-hour urine collection. These findings should now be confirmed in larger patient populations including early stage plasma cell disorders, light chain amyloidosis and symptomatic MM.

First Page

449

Last Page

453

DOI

10.1016/j.clml.2025.01.003

Volume

25

Issue

6

Publication Date

6-1-2025

Medical Subject Headings

Humans; Multiple Myeloma; Proteinuria; Creatinine; Prospective Studies; Male; Female; Middle Aged; Aged; Adult; Urinalysis; Aged, 80 and over; Urine Specimen Collection

PubMed ID

39893097

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