Title

Immunodeficiency Secondary to Malignancies and Biologics

Editor

Bernstein, Jonathan A.

Department

Allergy and Immunology

Document Type

Book Chapter

Publication Title

Primary and Secondary Immunodeficiency: A Case-Based Guide to Evaluation and Management

Abstract

There are many causes for secondary immunodeficiency (SID), which commonly presents with increased risk of infections. B-cell malignancies (multiple myeloma, chronic lymphocytic leukemia, non-Hodgkin’s lymphoma) and chemotherapeutics with B-cell depleting treatments such as rituximab are increasingly recognized risk factors for SID. This chapter discusses the diagnostic approach to patients with SID due to malignancy and biologics, including evaluation of immunoglobulin (Ig) levels and the importance of assessing a vaccine response. The chapter also discusses management options with prophylactic vaccination, prophylactic antibiotics, and Ig replacement (IgR), with a discussion on the pros and cons of intravenous versus subcutaneous administration of IgR.

DOI

10.1007/978-3-030-57157-3_21

Publication Date

2021

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