Outcomes of urgent versus nonurgent transcatheter aortic valve replacement


Internal Medicine

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Catheterization and Cardiovascular Interventions


Background: There is a paucity of data regarding the outcomes of transcatheter valve replacement (TAVR) performed in an urgent clinical setting. Methods: The Nationwide Inpatient Sample (NIS) database years 2011–2014 was used to identify hospitalizations for TAVR in the urgent setting. Using propensity score matching, we compared patients who underwent TAVR in nonurgent versus urgent settings. Results: Among 42,154 hospitalizations in which TAVR was performed, 10,114 (24%) underwent urgent TAVR. There was an uptrend in the rate of urgent TAVR procedures (p =.001). The rates of in-hospital mortality among this group did not change during the study period (p =.713). Nonurgent TAVR was associated with lower mortality (odds ratio [OR] = 0.78; 95% confidence interval [CI]: 0.69–0.89, p <.001) compared with urgent TAVR. Nonurgent TAVR was associated with lower incidence of cardiogenic shock (OR = 0.46; 95%CI: 0.40–0.53 p <.001), use of mechanical circulatory support devices (OR = 0.69; 95%CI: 0.59–0.82, p <.001), AKI (OR = 0.60; 95%CI: 0.56–0.64 p <.001), hemodialysis (OR = 0.67; 95%CI: 0.56–0.80 p <.001), major bleeding (OR = 0.94; 95%CI: 0.89–0.99 p =.045) and shorter length of stay (7.08 ± 6.317 vs. 12.39 ± 9.737 days, p <.001). There was no difference in acute stroke (OR = 0.96; 95%CI: 0.81–1.14, p =.636), vascular complications (OR = 1.07; 95%CI: 0.89–1.29, p =.492), and pacemaker insertions (OR = 0.92; 95%CI: 0.84–1.01, p =.067) between both groups. Among those undergoing urgent TAVR, subgroup analysis showed higher mortality in patients ≤80 years (p =.033), women (p <.001), chronic kidney disease (p =.001), heart failure (p <.001), and liver disease (p =.003). Conclusion: In this large nationwide analysis, almost a quarter of TAVR procedures were performed in the urgent settings. Although urgent TAVR was associated with higher mortality and increased complications compared with nonurgent TAVR, the absolute difference in in-hospital mortality was not remarkably higher. Thus, urgent TAVR can be considered as a reasonable approach when indicated.

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