Scholarly publications and presentations by Rochester Regional Health's Research department authors.

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Submissions from 2023

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Acute otitis media pneumococcal disease burden and nasopharyngeal colonization in children due to serotypes included and not included in current and new pneumococcal conjugate vaccines, Michael Pichichero, Richard Malley, Ravinder Kaur, Robert Zagursky, and Porter Anderson

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Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers, Seth P. Jones, Kali H. Cook, Melody L. Holmquist, Liam J. Almekinder, Annie M. Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E. Pichichero, Ravinder Kaur, Lea V. Michel, and Michael L. Gleghorn

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Window of Susceptibility to Acute Otitis Media Infection, Peter Bajorski, Naoko Fuji, Ravinder Kaur, and Michael E. Pichichero

Submissions from 2022

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Antibiotic Use and Vaccine Antibody Levels, Timothy J. Chapman, Minh Pham, Peter Bajorski, and Michael E. Pichichero

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Computational prediction of intracellular targets of wild-type or mutant vesicular stomatitis matrix protein, Matthew C. Morris, Thomas M. Russell, Cole A. Lyman, Wesley K. Wong, Gordon Broderick, and Maureen C. Ferran

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Haemophilus influenzae Protein D antibody suppression in a multi-component vaccine formulation, Lea V. Michel, Ravinder Kaur, Michael L. Gleghorn, Melody Holmquist, Karin Pryharski, Janai Perdue, Seth P. Jones, Niaya Jackson, Isabelle Pilo, Anna Kasper, Natalie Labbe, and Michael Pichichero

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Harnessing the Proteome in COPD to Identify Individuals Vulnerable to Frequent Exacerbations, S Sethi, Matthew Morris, Spencer Richman, X Zhu, S Shen, S Qian, M J. Mammen, J Qu, and Gordon Broderick

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High Fidelity Modeling of Pulse Dynamics Using Logic Networks, Cole A. Lyman, Matthew M. Morris, Spencer Richman, and Gordon Broderick

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Identification of Novel Biomarkers for COPD Phenotypes by Large-Scale Proteomics Analysis with UHR-IonStar, S Sethi, X Zhu, S Shen, S Qian, Gordon Broderick, Matthew Morris, Manoj J. Mammen, and J Qu

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Interferon-γ promotes monocyte-mediated lung injury during influenza infection, Taylor Schmit, Kai Guo, and Michael E. Pichichero

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Leveraging Drug-Target Interaction Data for the Translation of Computational Models into Clinically Actionable Interventions, Spencer C. Richman, Cole A. Lyman, Matthew C. Morris, and Gordon Broderick

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Lipidation of Haemophilus influenzae Antigens P6 and OMP26 Improves Immunogenicity and Protection against Nasopharyngeal Colonization and Ear Infection, Ravinder Kaur and Michael E. Pichichero

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Mapping the network biology of metabolic response to stress in posttraumatic stress disorder and obesity, Thomas P. Chacko, J Tory Toole, Spencer Richman, Garry L. Spink, Matthew J. Reinhard, Ryan C. Brewster, Michelle E. Costanzo, and Gordon Broderick

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Network Modeling of Complex Time-Dependent Changes in Patient Adherence to Adjuvant Endocrine Treatment in ER+ Breast Cancer, Eileen H. Shinn, Brooke E. Busch, Neda Jasemi, Cole A. Lyman, J Tory Toole, Spencer C. Richman, William Fraser Symmans, Mariana Chavez-MacGregor, Susan K. Peterson, and Gordon Broderick

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Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine storm, Spencer Richman, Cole Lyman, Anastasia Nesterova, Anton Yuryev, Matthew Morris, Hongbao Cao, Chris Cheadle, Gary Skuse, and Gordon Broderick

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Pathogenesis of Streptococcus pneumoniae serotype 3 during natural colonization and infections among children and its IgG correlate of protection in a mouse model, Naoko Fuji, Michael Pichichero, and Ravinder Kaur

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Probing the potential interactions between two protein vaccine candidates from Nontypeable Haemophilus influenzae, Grace McGinnity, Janai Perdue, Natalie Labbe, Ravinder Kaur, Melody Holmquist, and Lea Michel

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Proteomic Network Analysis of Bronchoalveolar Lavage Fluid in Ex-Smokers to Discover Implicated Protein Targets and Novel Drug Treatments for Chronic Obstructive Pulmonary Disease, Manoj J. Mammen, Chengjian Tu, Matthew C. Morris, Spencer Richman, William Mangione, Zackary Falls, Jun Qu, Gordon Broderick, Sanjay Sethi, and Ram Samudrala

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Randomized Mechlorethamine/Chlormethine Induced Dermatitis Assessment Study (MIDAS) Establishes Benefit of Topical Triamcinolone 0.1% Ointment Cotreatment in Mycosis Fungoides, Carolina V. Alexander-Savino, Catherine G. Chung, Elaine S. Gilmore, Sean M. Carroll, and Brian Poligone

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Refinement of Biological Regulatory Graphs using Functional Enrichment, Jeffrey M. Page, Matthew C. Morris, Gary Skuse, and Gordon Broderick

Submissions from 2021

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Attractor Landscapes as a Model Selection Criterion in Data Poor Environments, Cole A. Lyman, Spencer Richman, Matthew C. Morris, and Gordon Broderick

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A Vaccine Candidate Case Study: Understanding Protein D Antibody Suppression by Omp26, Anna Kasper, Niaya Jackson, and Ravinder Kaur

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Can Machine Learning and AI Replace Otoscopy for Diagnosis of Otitis Media?, Michael E. Pichichero

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Comparison of Specific In-vitro Virulence Gene Expression and Innate Host Response in Locally Invasive vs Colonizer Strains of Streptococcus Pneumoniae, Naoko Fuji, Michael E. Pichichero, and Ravinder Kaur

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Gulf War Illness Clinical Trials and Interventions Consortium (GWICTIC): A Collaborative Research Infrastructure for Intervention and Implementation, Amanpreet K. Cheema, Rebecca B. McNeil, Travis Craddock, Gordon Broderick, Maria M. Abreu, Kristina Aenlle, Drew A. Helmer, J Wesson Ashford, Kimberly Sullivan, Alison Bested, Devra E. Cohen, Dikoma Shungu, Helena Chandler, Mary Ann Fletcher, Maxine Krengel, and Nancy Klimas